Beyonce’s father, Mathew Knowles has undergone a breast cancer surgery.
Mathew Knowles is an American record executive, entrepreneur, and university instructor. His role as Destiny’s Child’s manager is what makes him most well-known. Additionally, he has overseen Beyoncé and Solange Knowles’ solo ventures.
In a video making the rounds online, Mathew Knowles narrated how he discovered he had breast cancer as he begged men to get tested.
He wrote, “Please, get tested! Early detection is critical, but many people don’t take it seriously enough. All of us should be making our health a priority and taking proactive measures to ensure we remain healthy and catch issues early. In this video, I share how I first discovered that I had cancer. I hope it inspires people to get tested and keep their health in focus.”
BRCA1 (BReast CAncer gene 1) and BRCA2 (BReast CAncer gene 2) are genes that produce proteins that help repair damaged DNA. Everyone has two copies of each of these genes—one copy inherited from each parent. BRCA1 and BRCA2 are sometimes called tumor suppressor genes because when they have certain changes, called harmful (or pathogenic) variants (or mutations), cancer can develop.
The risks of various cancers—most notably breast and ovarian cancer, but also several other types of cancer—are elevated in people who inherit dangerous mutations in one of these genes. People who inherit a risky variation in BRCA1 or BRCA2 also have a tendency to get cancer earlier in life than those who do not.
Either parent can pass on a risky BRCA1 or BRCA2 mutation to their child. A 50% probability (or 1 in 2) exists for each child of a parent who carries any mutation in one of these genes will inherit the mutation. All body cells begin life with inherited mutations, often known as germline mutations or variations.
Even if a person got a dangerous version of the BRCA1 or BRCA2 gene from one parent, they would have inherited a healthy copy of that gene from the other parent (because most detrimental variant-carrying embryos are unable to develop). But during the course of a person’s lifetime, the typical copy may disappear or change in some bodily cells. A somatic alteration is what we refer to as such a transformation. Without any functional BRCA1 or BRCA2 proteins, cells can proliferate out of control and develop into cancer.